Drug metabolism is a crucial aspect of medical practice and pharmacology, involving the transformation of drugs by various bodily systems to create compounds that are more easily eliminated from the body. Cytochrome P450 (CYP) enzymes, predominantly found in hepatocyte endoplasmic reticulum, play a central role in metabolizing numerous small molecule drugs through diverse oxidative and reductive biotransformations. The study of absorption, distribution, metabolism, and excretion (ADME) is integral to drug design, exploring the fate of drug molecules post-administration. Rosmarinus acid, soluble in ethanol and found in Rosemary leaves, has demonstrated therapeutic benefits in conditions such as cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver disease. In pharmacokinetic research, the six phenolic acid compounds in Rosemary exhibited superior properties compared to the reference ligand Sorafenib.