The present research study has examined the relationship between vocational interest and socio-economic status of senior secondary school students. The sample consisted of 120 senior secondary students studying in 11th and 12th class of different Government and private schools of Mayurbhanu district of Odisha. The sample were drawn through random sampling techniques. A self-developed Vocational Interest Scale (VIS) was used to measure the vocational interest of the students. Result provided evidence that there is significant relationship between vocational interest and socio-economic positive socio-economic status had significant impact on the vocational interest of students. It was also found that the students those were high socio-economic status had better vocational interest.