Thermodynamics can be viewed as one of the major branches under physical science which deals with energy transformations. Transfer of energy from one zone to another, its temperature, pressure, intensity and other thermal variables coming under thermodynamics. Human dynamics stands for the science which has a look on activities of human such as transfer of ideas, emotions, and interactions through different nature of relationships in human life. It can be considered as the ‘in depth’ detailing of interpersonal relationships and behavioral pattern exhibited by human beings as a result of stimulus and response in different occasions. Present study is an attempt to appreciate the comparison between thermodynamics and human dynamics. Even though there exists no significantly evident similarities between thermodynamics and human dynamics, by comprehensive evaluation we can find out the close matching between two branches. The exchange and conversion of energy are the fundamental aspects connect these two domains. Thermodynamics deals with the principles governing energy changes in physical system, while human dynamics involves understanding and managing energy in human interactions, emotions and behavior. This paper aimed to analyze the implication of different laws of thermodynamics especially zeroth law of thermodynamics have significant similarity with human life. According to the reflections of the paper, laws of thermodynamics have a significant impact on human life.