The investigation into dyslipidemia, associated with an increased cardiovascular risk, focuses on evaluating the effectiveness of garlic extract (Allium sativum) in reducing lipid levels in rats subjected to a high-fat diet and PTU (propylthiouracil). Elevated lipids significantly contribute to cardiovascular diseases, emphasizing the importance of effective management for prevention. This study explores the antidyslipidemic potential of Garlic (Allium sativum) using male Wistar rats in a Pre-test and Post-test group-only control design. Phytochemical screening revealed the presence of various compounds, including Alkaloids, Saponins, Flavonoids, Tannins, Steroids, and Terpenoids, in the methanol extract of garlic. The research concludes that this extract significantly reduces total cholesterol, triglycerides, and LDL levels while increasing HDL levels in experimental rats. Notably, the decrease in SGOT levels positively impacts liver health, potentially reducing the risk of Non-Alcoholic Fatty Liver Disease (NAFLD). Despite promising findings, further confirmation through human studies is necessary before considering Garlic (Allium sativum) methanol extract as an effective therapy. With observed improvements in lipid profiles and liver health, the methanol extract of garlic holds potential as an active ingredient for developing antidyslipidemia therapy.