Tuberculosis (TB) which is caused mainly by Mycobacterium tuberculosis (MTB), led to 1.3 million deaths and 10 million (5.8 million men, 3.2 million women, and 1.0 million children) newly clinical cases in the year of 2017 according to the World Health Organization (WHO) 2018 report. Moreover, the numbers are in continual increase, especially in developing countries. There are several reasons responsible for this situation, and the wide spread of drug resistant TB (DR-TB), multidrug resistant TB (MDR-TB), and coinfection with HIV, as well as the emergence of extensively drug resistant TB (XDR-TB) and totally drug resistant TB (TDR-TB) are the major reasons.