This study explores the potential of Turmeric (Curcuma longa Linn) as an antipyretic analgesic with flavonoid content in its methanol extract that can inhibit prostaglandins and reduce pain and fever. Although its use is still limited in Indonesia, this study aims to understand the analgesic and antipyretic effects of Turmeric methanol extract on male Wistar rats. The experimental design used the Post-Test Only Control Group to evaluate the antipyretic and analgesic effects at Prima Indonesia University Laboratory in January 2024. An acetic acid writhing test assessed an analgesic activity using a 0.7% acetic acid solution. The results showed the potential of Turmeric extract as an antipyretic and analgesic in male Wistar rats, especially at the highest dose (600 mg/kg body weight) after 5 hours of administration. The effect was more significant than the control and Standards groups, with hematological analysis showing increased extract dose. These findings support turmeric as a candidate for developing more effective antipyretic and analgesic drugs.