This study aims to evaluate the factors that influence exclusive breastfeeding practices at the MCH clinic of Royal Prima Hospital Medan in 2024. Breast milk is an essential source of nutrition for infants due to its balanced composition, providing optimal support for their growth and development. In this study, the method used was non-experimental quantitative research with a descriptive approach and associative analysis. The study population included 144 individuals, with 110 respondents taken as samples through an incidental sampling technique based on predetermined criteria. Data analysis used univariate, bivariate, and multivariate approaches to evaluate independent variables such as Age, Education Level, Employment Status, Knowledge, Attitude, and Family Support on the dependent variable, exclusive breastfeeding. The analysis showed that all independent variables had a significant association with exclusive breastfeeding, with a p-value ≤ 0.05, which rejected the null hypothesis. Notably, the knowledge variable had the highest Odds Ratio (OR), indicating that a higher level of knowledge in mothers was associated with a greater chance of exclusively breastfeeding their infants. In conclusion, a better understanding of the benefits of exclusive breastfeeding could be an essential factor in improving exclusive breastfeeding practices in the community.