The study aimed to investigate the influence of learner-oriented instruction of teachers on the data interpretation skills of students. In this study, the researcher selected the 212 elementary school teachers in Manay South District in Davao Oriental as the respondents of the study. Stratified random sampling technique was utilized in the selection of the respondents. Non-experimental quantitative research design using descriptive-correlational method was employed. The data collected were subjected on the following statistical tools: Mean, Pearson Moment Product Correlation and Linear Regression Analysis. Findings revealed that learner-oriented instruction of teachers and data interpretation skills of students in Manay South District in Davao Oriental were described as moderately extensive. Further, correlation analysis demonstrated that there is a significant relationship between learner-oriented instruction of teachers and data interpretation skills of students in Manay South District in Davao Oriental. Evidently, regression analysis proved that learner-oriented instruction of teachers in terms of learner empowerment; self-directed learning; and active learning engagement significantly influenced the data interpretation skills of students in Manay South District in Davao Oriental. The study, therefore, conducted for further utilization of findings through publication in reputable research journal.