The main objective of this study was to determine the level of personal and professional challenges of Social Workers in Crisis Intervention Section of the Department of Social Welfare and Development Region 4A in relation to situation and performance in a disaster response. The descriptive design was used in gathering the information, Pearson Product Movement Correlation Coefficient (r) is used in determining the significant relationship between the level of Social Workers’ challenges in terms of personal and professional and their level of activity in terms of situation and performance. Chi-squared test was used to test the significant relationship between the demographic profile of the respondents and their level of challenges in terms of personal and professional; significant relationship between the demographic profile of the respondents and their level of activity in terms of situation and performance. The mean and standard deviation was utilized to determine the level of challenges of the Social Workers in term of Personal such as Emotional and Psychological Challenges, Physical Challenges, and Safety and Security; on the other hand, Professional such as Work-Life Balance, Support and Resources, Guilt, Shame and Burnout and training and experiences of the respondents. Also, mean and standard deviation was utilized to determine the level of activity of the Social Workers in term of Situation such as Severity of disaster, Resources available, support from colleagues and supervisors and types of disaster; on the other hand, Performance such as Effectiveness, Efficiency, Quality and Safety of the respondents. The data acquired were treated and examined using frequency and percentage distribution to determine the demographic profile of the Social Workers in term of, age, sex, civil status, employment status, family income, and number of years in service. Result shows that there is no statistically significant relationship using the above mentioned statistical tests was detected between the level of challenges in terms of personal and professional, social worker’s level of activity in terms of situation and performance and social workers’ challenges and their level of activity. Furthermore, the study concludes that the personal and professional challenges of social workers under Crisis Intervention Section of the Department of Social Welfare and Development Region 4A in Relation to Situation and Performance in a Disaster Response as perceived by the respondents, social workers are bounded to what they ought to do and the unwritten duties and obligation that are expected which includes the duty to the profession that requires a professional social worker to maintain with high standard of commitment with positive attitude to take responsibilities. Thus, it is recommended that the social workers under crisis intervention release the importance of job tenure for their security. That the Department of Social Welfare and Development 4A request for more creation of permanent or contractual positions especially for those staffs that give and rendered their time, skills, commitment and collaborative efforts that contributed for a successful program implementation, That the national government specifically the legislature department must enact and amend the Magna Carta for Social workers that compensate social workers regardless on their employment status when it comes to disaster response. Lastly, that the Department of Social Welfare and Development 4A invest for capacity building activities for the social workers and other support staffs in relation to disaster response. It is important that front liners during disaster response possess strong set of skills and properly trained.