This paper addresses the conceptual delineation and content-related aspects of “lexico-semantic groups” (LSGs) and “functional-semantic classes” (FSCs) of words. It aims to elucidate and define these linguistic categories, establishing their structural and semantic characteristics. Furthermore, it examines the complexity and multidimensionality of semantic relationships in language, and articulates criteria for distinguishing between LSGs and FSCs. The conclusion posited is that lexico-semantic groups constitute a primary framework for the categorization of vocabulary, which facilitates an understanding of the operational dynamics of lexico-semantic groups of verbal predicates at the contemporary stage of linguistic evolution.