Infertility is a widespread global concern impacting millions of couples, posing challenges in achieving pregnancy despite regular unprotected intercourse. This study delves into the intricate repercussions of infertility on individuals and couples, spanning physical, emotional, and social realms. Female infertility stems from various factors like age, physiological dysfunctions, and lifestyle choices, while male-specific issues revolve around sperm quality and quantity. Psychological ramifications of infertility are profound, with a higher prevalence of depression observed among infertile individuals compared to fertile counterparts. Quality of life assessments highlight significant correlations with educational levels, economic status, age, duration of infertility, and marital duration. Patient-reported outcome measures like the FertiQoL and Fertility Problem Inventory provide valuable insights into assessing infertility-related quality of life. Addressing depression, fatigue, and marital intimacy emerges as pivotal strategies to enhance the overall well-being of infertile individuals. This review underscores the imperative of adopting a holistic approach to comprehend and tackle the multifaceted challenges posed by infertility.