Kala is the inevitable and the cause of everything that happens. According to the description, Anayathasiddha Nimitta Karana, there can be no action without the effect of kala. So Ayurveda being the science of life, gives huge emphasis on the concept of Kala.TrisutraAyurved is of prime importance while treating a patient. Hetu (causative factors), linga (signs and symptoms) and ausadha (medicine) are considered as TrisutraAyurved. Since Agni is the most important element in preserving Dhatu Samya, all therapeutic approaches aim to maintain and retain the potency of Agni. Ausadha Sevan Kala will help in food and drug interaction which is helpful to attain a quick and sustainable relief to the patient. kala, is a crucial component that needs to be consideration while treatment.Our acharyas have explained the relationship of kala and dosha while treating a disease .These days, treating a patient does not take this relationship into consideration. Agnimandya is the condition when the Agni's activity is inhibited, which causes food even small amounts to be partially or partially digested or to be indigestion. Ayurvedic classics suggest that poor lifestyle choices, such as poor eating habits, irregular sleep patterns, stress, and so on, are the primary causes of agnimandya. Therefore, practically all diseases that are caused by Agnimandya can be treated or prevented with this in perspective.