Ayurveda consider Health and Disease both as the products of food and life style. Today when population is moving with modernization in the 21st century a lot of new diseases emerge out due to faulty life style, unhealthy food, lack of exercise, mental stress and disturb sleep. All these disturbs the biological clock of human being and produce new life style diseases. Ajirna is a common disease which originates from digestive power insufficiency (Agni) due to all above factors of modern Era. Ayurveda is the ancient Indian system of medicine, deals with management and prevention of disease. It has given prime importance to Agni, as it is one of the basic biological elements of the living body. It is having Its own physical characteristics, location,function and secretions like digestive juices and enzymes which participate in the digestion and metabolic functions. Therefore, Ayurveda considers Dehagni as the cause of life, Complexion, Strength, Health, Oja, Teja (energy) and Prana. Derangement of Agni is one of the root cause for development of diseases. Ajirna arises as a result of less/excessive/ irregular digestion of food and this further produce Ama which circulate all over the body. Ama combine with other Dosas and Dushyas, vitiate them, produce many diseases. Preventive measures like Dincharya, Ratricharya, Ritucharya, Sadvrita, pathya bhojana Grahan are helpful to reduce the Ajirna Avastha in patient.