Dhatus are important structures as they hold the body and provide nutrition to the body. Any kind of disturbance in dhatus can affect body to a large extend and could be a result of various disorders. Knowledge of involved Dosha, creating structural or functional disturbance in any particular Dhatu is highly beneficial in the field of treatment. Rakta dhatu is the second Dhatu which is responsible for Jivan or life in the body[2]. If Rakta Dhatu gets vitiated by the Doshas then it leads to Rakta pradoshaja vikara. Acharya Charak has considered Kushtha, Visarpa, Pidaka, Raktapitta, Asrigdara, Gudapaka, Medhrapaka, Ashyapaka, Plihavridhi, Gulma, Vidradhi, Nilika, Kamala, Vyanga, Piplu, Tilakalaka, Dadru, Charmadala, Switra, Pama, Kotha, Ashramandala[3] under Raktapradoshaja Vikara which are seen widely now a days. Hence an attempt is made to elaborate the involvement of different Doshas in Rakta pradoshaja vikara for getting accurate treatment.