The study determined the teachers' competence and awareness in integrating global issues into the Science curriculum and its effect on students’ academic behavior and performance. Specifically, this research sought to determine teachers' competence and awareness in integrating global issues in the science curriculum into the academic behavior and performance. This research also sought to determine the significant relationship between teachers' competence and awareness of integrating global issues in the science curriculum and students' academic behavior and performance. The study used a descriptive design to utilize and analyze the data systematically. It was conducted at San Antonio Integrated National High School, Division of Laguna. The total population utilized in this study was 84 Grade 10 students. A self-made questionnaire was utilized and validated among 3 Science Master teachers. Findings revealed that the teachers’ competence was found to be of "Very Great Extent," while teachers' awareness was also found to be of "Very Great Extent." Likewise, the student's academic behavior was also observed as a "Very Great Extent." However, students' academic performance was interpreted as "Satisfactory". The research revealed a significant relationship between teachers' competence and awareness and students' academic behavior and performance. Data revealed that teachers’ competence and awareness in the integration of global issues into the Science curriculum were found to have a relationship to academic behavior and performance. Thus, signified rejection of null hypotheses. This indicates that higher teacher competence is associated with lower levels of academic behavior. Moreover, students’ positive behaviors fosters when teachers possess deep understanding of diverse perspective, pedagogical methods, and alignment with educational goals. Furthermore, teachers’ competence and awareness play a role in shaping students’ academic performance. It is recommended that teacher engagement in ongoing professional development be prioritized to stay updated on the latest trends, research, and best practices in integrating global issues into the science curriculum. Teachers should also analyze the factors contributing to students' satisfactory performance and implement targeted strategies to address any gaps or challenges.