The study intended to explore the relationship between workplace spirituality and teacher’s self-efficacy among higher secondary teachers in Kerala. Specifically, this study finds out the level of workplace spirituality and teacher’s self-efficacy among teachers and to find out the relationship between workplace spirituality and teacher’s self-efficacy and also examine how the demographic variables influence workplace spirituality and teacher’s self-efficacy. A structured questionnaire of workplace spirituality and teacher’s self-efficacy is used for the study. Data was collected from 200 respondents by using purposive random Sampling technique. The findings of the study shows that there is high level of workplace spirituality and teacher’s self-efficacy among higher secondary teachers in Kerala. And also reveals that there is positive relationship between workplace spirituality and teacher’s self-efficacy and there is no difference between male and females in their level of spirituality at work and self-efficacy.