Gridhrasi (sciatica) is a condition characterized by radiating pain along the sciatic nerve, often due to lumbar disc herniation, spinal stenosis, or trauma. In Ayurveda, Gridhrasi is considered a disorder caused by an imbalance of Vata dosha. This case series examines the efficacy of Ayurveda therapies in managing Gridhrasi. Five patients presenting with symptoms of radiating pain, stiffness, and heaviness were treated using Panchakarma therapies including Snehana (oleation), Swedana (sudation), and Basti (medicated enema), along with internal medications such as Maharasnadi Kashaya, Sahacharadi Kashaya, and Manjishtadi Kashaya, all known for their anti-inflammatory and Vatahara properties. The patients underwent personalized treatment protocols combining Bahya chikitsa like Katibasti, Patra Pinda Sweda, and abhyanga (massage) with Abhyantara chikitsa. Yoga Basti, incorporating Anuvasana and Niruha Basti, was central in pacifying Vata and nourishing the dhatu. Outcomes were assessed based on both subjective and objective criteria, including pain scores, toda, stamba, gourava, and Straight Leg Raise (SLR) test results. Post-treatment assessments revealed significant reductions in symptoms, and improved mobility across all cases, demonstrating the effectiveness of this Ayurveda treatment protocol. These findings suggest that Ayurveda treatment offers a promising-term management of Gridhrasi by addressing both the root cause and symptoms. Further research with larger sample sizes and clinical trials is warranted to establish the broader applicability of these findings.