Postpartum depression (PPD) is a debilitating mental health disorder that affects a significant proportion of new mothers worldwide. If untreated, PPD can interfere with maternal-infant bonding, impair breastfeeding, and disrupt family dynamics. Nurses, being the first point of contact in postpartum care, play a pivotal role in recognizing and managing PPD through screening, early interventions, psychoeducation, and providing emotional and practical support. This article offers a comprehensive review of the role of nursing in the prevention, detection, and management of PPD. It highlights evidence-based interventions, the importance of family-centered care, and the need for collaborative, multidisciplinary approaches to address the unique needs of affected women. Challenges in nursing care, including cultural stigma and time limitations, are also discussed, along with strategies to overcome these barriers.