The paper reviews Human hydatid cyst or cystic echinococcosis is a life-threatening zoonotic disease that occurs in most countries worldwide and is recognized as a major public health problem. Following, ingestion of Echinococcus granulosus eggs, hydatid cysts which is the larval stage of the worm are formed mostly in liver and lungs, and occasionally in other organs of human,the infection with hydatid disease effect on the liver and lung function after examination of some biochemical parameters that related to liver and lung function,. Aspartate Total Protein, Total Bilirubin, Aminotransferase (AST), Lactate Dehydrogenase (LDH) were decrease while aspartate Blood Urea Nitrogen (BUN), Creatinine, Albumin has increase,Values of hemoglobin and red blood cells and packed cell volume in sheep infested by E. granulosus, appear low compared with reference values. While hyper eosinophilia, lymphocyte and monocyte was high, and this typical of parasitic diseases. In mice Balb\c strain and sheep found that the number of white blood cell has increase (eosinophilia, lymphocyte and monocyte) and decrease of neutrophils after counting the differential WBC of positive group and increase of MCV, MCH, MCHC.