Objectives: This study was conducted to estimate the medication adherence, reported side effects and general functioning among caregivers of patient receiving antipsychotic medication, to determine the effect of a multicomponent intervention program on medication adherence, reported side effects and general functioning among caregivers of patient receiving antipsychotics and to find the association of medication adherence, reported side effects and general functioning with selected socio personal variables. Methods: A quantitative research approach and one group pre test post test design were adopted. Using convenience sampling, 80 caregivers of patient receiving antipsychotic medication who attended psychiatric outpatient department were enrolled in the study. Socio personal proforma, Clinician rating scale, Glasgow antipsychotic side effect scale and Lawton instrumental activities of daily living scales were used to collect the data. Results: Findings of the study showed a significant difference in the pre and post test results of medication adherence (z = 4.256) at p<0.001, reported side effects (z = 4.302) at p<0.001 and general functioning (z = 4.218) at p<0.001 scores after the multicomponent intervention program. The study also found that, there was no significant association between medication adherence, reported side effects and general functioning with the selected socio personal variables. Conclusion: The study concluded that multicomponent intervention program helps to provided medication adherence, management of antipsychotic side effects and improved the general functioning among caregivers of patient receiving antipsychotics. Keywords: Multicomponent intervention program, Medication adherence, Reported side effects, General functioning, Caregivers of patient receiving antipsychotics.