Dengue is a viral mosquito-borne disease and is known to possess threat to public health on large scale. Carica Papaya leaf extract (CPLE) is a natural remedy that has demonstrated promising way to comb-act dengue symptoms by increasing platelet levels in dengue patient. This review also highlights PLE's efficacy in treating dengue, alongside its various health benefits, including Immunomodulation, Antioxidant activity, Anti-cancer and Anti-viral properties. Hepatoprotective and Gastroprotective effects, Cardiovascular health and Anti-diabetic potential. Various novel formulation strategies to enhance PLE's treatment efficiency and to overcome stability issues are under study which are discussed in short. Also highlights the existing challenges for use of papaya in health condition and required future research directions that will uncover potential of papaya leaf extract in medical science.