Pulsatile Drug Delivery Systems (PDDS) are innovative, time-controlled systems that manage drug release independently of external factors like pH, enzymes, and gastrointestinal motility. Traditionally, drugs are released either immediately or over an extended period. However, pulsatile release systems have garnered significant interest recently, as they align with the body's circadian rhythms—where "circa" means "day" and "dian" means "night" in Latin. These systems are designed to release medication rapidly after a defined lag time, offering potential advantages for various therapies. PDDS show promise for treating conditions such as asthma, peptic ulcers, cardiovascular diseases, arthritis, attention deficit hyperactivity disorder in children, and hypercholesterolemia. By synchronizing drug delivery with the body's internal clock, these systems ensure that medications are administered at optimal times, which can enhance therapeutic outcomes for chronic conditions like arthritis, asthma, and hypertension. The goal is to achieve complete and rapid drug release post-lag time, thus providing patients with timely and effective treatment.