Introduction Earthworm (Pheretima posthuma) and plant (Lantana camara) extracts have been used for centuries to treat a variety of ailments; they have been shown to inhibit the growth of numerous harmful bacteria and are particularly useful for wound healing. To determine which is more effective for creating antiseptic ointment, we evaluated the antibacterial activity of the various organic extracts derived from these species against harmful bacterial strains. The disk diffusion and shaking flask tests were utilized to determine the antibacterial activity of the ethanol and acetone solvents employed for the extraction. Next, we determined the extracts' lowest inhibitory concentrations against both gram-positive and gram-negative microorganisms. When it came to Pseudomonas aeruginosa, Lantana camara exhibited the biggest growth inhibitory zone, followed by Serratia marcescens and StaphylococcusAureus is the abstract. While earthworm extract inhibited growth at a minimum level of 200μg/ml, plant extract had a minimum inhibitory concentration (MIC) of 150μg/ml. In contrast to the worm extract, we discovered that the ethanol extract of the plant (L. camara) demonstrated strong antibacterial activity. The use of Lantana camara extract to create an ointment to treat wound infections is supported by current research.