Base isolation is one of the most powerful tools of earthquake engineering pertaining to the passive structural vibration control technologies. It limits the effects of the earthquake attack through a flexible base which decouples the structure from the ground motion, and the structural response accelerations are usually less than that of the ground acceleration. . For this Three dimensional nonlinear time history analysis is performed on r/c building by the use of computer program SAP 2000 v12.0.0. The dynamic analysis of the structure has been carried out and the performance of the building with and without isolator is studied. The main objective here is to make seismic response control by providing Isolators and comparing between the fixed based and isolated base building. Rubber bearing and Friction pendulum bearing are used.