The study of antibiotic usage profiles in health centers is critical for understanding prescribing patterns, evaluating antimicrobial stewardship, and managing antibiotic resistance. This review synthesizes findings from various studies on the types, dosages, and frequency of antibiotics administered in primary healthcare settings. Key antibiotics commonly prescribed include broad-spectrum agents such as penicillins, cephalosporins, and fluoroquinolones, often used for respiratory, urinary, and gastrointestinal infections. The review highlights both appropriate uses and frequent issues, such as overprescription, misuse, and lack of adherence to guidelines, which can accelerate antimicrobial resistance. Additionally, it discusses the role of healthcare providers' training, patient demand, and institutional guidelines in influencing prescription practices. Recommendations for optimizing antibiotic use include implementing strict guidelines, increasing awareness about antimicrobial resistance, and enhancing diagnostic capabilities in health centers. This review underscores the importance of careful antibiotic monitoring in primary care to ensure effective treatments while mitigating the risks associated with resistance development