The present study was to determine the potential of a nanoemulsion for drug delivery of aceclofenac using different excipients (almond oil) having good solubility. The nanoemulsion was formulated in o/w type emulsion by using different method of preparation that is High-Pressure Homogenization Method.this type of nanoemulsion contains aceclofenac which has anti-inflammatory property and almond oil make skin hydrated Aceclofenac-loaded nanoemulsions were prepared using a high-energy emulsification method, optimizing factors like surfactant concentration, oil-to-water ratio, and homogenization conditions. The resulting nanoemulsion demonstrated a droplet size below 200 nm, a narrow polydispersity index, and high drug encapsulation efficiency. Physicochemical properties such as pH, viscosity, and stability under various storage conditions were evaluated. Nanoemulsions are advanced drug delivery systems known for their potential to enhance the solubility, stability, and bioavailability of poorly water-soluble drugs. This study focuses on the development and characterization of a nanoemulsion containing aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), and almond oil as a lipid carrier. Almond oil, rich in essential fatty acids and antioxidants, serves as a natural and biocompatible oil phase, improving drug stability and promoting skin penetration.