Mr. Parmeshwar Matlabe, Rutuja Nehru Kabre, Yogeshwari.B.Pamane, Sonali.A.Ghorpade, Swapnil.S.Parve, Renuka.V.Wagh
Raosaheb Patil Danve College of Pharmacy, Badnapur, Jalna, Maharashtra
Abstract
Suppositories are vital pharmaceutical dosage forms that play an important role in drug delivery. These dosage forms are placed into body cavities, primarily the rectum and vagina, to transmit medication into systemic circulation. Patients who cannot take medications orally due to conditions such as nausea, vomiting, or neurological disorders can utilize suppositories. Suppositories are preferred over other dosage forms because they are available in various shapes and sizes. They represent a highly practical method of administering medication. It can be made using different bases such as cocoa butter, PEG, and fat as primary components. The preparation can be done through methods like hand rolling, compression molding, fusion molding, and automatic molding techniques. Evaluation tests include checks for weight uniformity, content uniformity, melting point determination, general appearance assessment, active ingredient assay, liquefaction time measurement, breaking strength test, disintegration test, and dissolution test[1].
Keywords: suppository, Avoid first pass metabolism, Evaluation tests , Rectal drug delivery system.
Journal Name :
EPRA International Journal of Multidisciplinary Research (IJMR)

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Published on : 2024-12-04

Vol : 10
Issue : 12
Month : December
Year : 2024
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