Pregnancy is a critical phase in a woman's life that requires attention to physical, mental, and social health. This process involves significant changes in physiological and psychological aspects that affect the health of the mother and fetus. Health surveillance during pregnancy, including antenatal care (ANC), is essential to prevent complications. However, in Indonesia, the use of ANC services is still not optimal, as it is influenced by various factors such as age, education, work, knowledge, and husband support. This study aims to analyze the factors that affect women's empowerment in decision-making for antenatal care at the Teluk Panji Health Center, South Labuhanbatu Regency. The method used was quantitative with a descriptive approach and associative analysis, involving 300 respondents of pregnant women who were selected incidentally. Data was obtained through interviews and questionnaires. The results showed that the education level had a p-value of 0.000, a p-value of 0.016 for employment status, a p-value for husband support of 0.000, and a p-value for health facility accessibility of 0.000. These variables are significantly related to women's empowerment in ANC decision-making. These findings provide important insights for policymakers and health practitioners to improve the quality of services and support for women's empowerment in antenatal care.