Around the globe, birth defects are the primary reason why many infants don't make it through their first year, and those who do survive often face enduring physical and mental challenges throughout their lives. Ayurveda explains 4 garbha sambhava samagris (factors essential for conception); Ritu, Kshetra, Ambu, and Beeja. The Ksetra and Ambu play important roles throughout the gestation period. Congenital anomalies can occur during the developmental stages of the embryo, from abnormal genetics passed on from the parents, or from vivid environmental factors. Teratogens are one of the major contributors causing fetal anomalies by affecting the prenatal environment which can be understood as Garbhopagathakara Bhavas (factors responsible for Damaging a fetus). A human teratogen is an agent that alters the growth or structure of the developing embryo or fetus, thereby causing birth defects. examples Alcohol, Tobacco (smoking), Thalidomide, Cocaine, Rubella, X-rays (ionizing radiation), Lead, Mercury, and Pesticides. Acharyas have mentioned Garbhini Paricharya and Garbhopagathakara Bhavas highlighting their importance during pregnancy. Teratogens are significant contributors to fetal anomalies, and their prevention is of paramount importance. By understanding the mechanisms by which teratogens operate and by implementing integrated effective prevention strategies, it is possible to reduce the incidence of birth defects and promote healthier pregnancies. Public awareness, guidance, and governmental regulations all play a vital role in safeguarding the developing fetus from the harmful effects of teratogenic exposures.