This research on "Chinese Herbal Medicine and Bird-and-Flower Painting Creation in Zhaoqing" provides an in-depth analysis of the cultural background of Chinese herbal medicines in Zhaoqing region and their integration with bird-and-flower painting art. The paper first explores the historical origins and modern legislative protection of Zhaoqing's Chinese herbal medicines, highlighting their core value in Lingnan traditional Chinese medicine culture. Subsequently, the paper analyzes the traditional foundation and innovative pathways of Zhaoqing's bird-and-flower paintings, with particular attention to how Chinese herbal medicines inject new cultural elements and artistic vitality into bird-and-flower paintings. Through detailed interpretation of masterpieces throughout history, the paper reveals the unique charm and profound implications of Zhaoqing's medicinal materials in artistic expression. Finally, the paper emphasizes the significant role of Zhaoqing's Chinese herbal medicine bird-and-flower painting creation in educational popularization, cultural inheritance, social influence, and cultural confidence building. This paper argues that Zhaoqing's Chinese herbal medicine bird-and-flower painting creation represents not only a paradigm of artistic innovation but also a crucial medium for inheriting and promoting traditional Chinese medicine culture.