Job dissatisfaction often results from high job demands combined with limited resources, which drives employees to engage in counterproductive behaviors to cope with complex conditions. This research aimed to examine work environment and work orientation as predictors of job satisfaction of non-teaching personnel in selected local colleges in the Davao Region. A quantitative method, particularly descriptive-correlational design, was used in the study. The 250 non-teaching personnel in selected local colleges in Davao Region were chosen using a purposive sampling technique. Mean, Standard Deviation, Pearson R, and Multiple Regression were the statistical procedures utilized to analyze the data gathered. Results showed that the level of work environment of non-teaching personnel is very high, the level of work orientation is high, and the level of job satisfaction is also high. These results imply that the work environment is very favorable, work orientation is positive, and employees are satisfied with their jobs. Moreover, work orientation and work environment pose a significant relationship with job satisfaction. Further, work orientation and work environment significantly predict employee job satisfaction. The regression model reveals that this study does not cover 78.0% of the factors that could significantly predict job satisfaction.