This study explored the mediating role of science interest in the relationship between students' engagement and attitudes toward science among Grade 10 students from public schools in Laak South District, Davao de Oro. Using a quantitative research design with a descriptive and correlational approach, data were collected from 249 Grade 10 students across three public secondary schools. To measure the level of student engagement, the scale used was The Students' Science Engagement Scale by Baraquia. Attitudes toward science were assessed using the Attitudes Toward Science Questionnaire by Al-Mutawah and Fateel while science interest was evaluated via the Biology Interest Questionnaire by Knekta et al. Results indicated a high level of engagement among students, moderate attitudes toward science, and a high level of science interest. The correlation analysis revealed significant interrelationships between the variables for student engagement and attitudes toward science, science interest and attitudes toward science, and students’ engagement and science interest. The relationship between student engagement and attitude toward science was partially mediated by science interest. All these findings indicate that developing both interest in science and student engagement can enhance attitudes toward science.