Glycyrrhizin, a key bioactive component of Glycyrrhiza glabra (Liquorice), is recognized for its significant pharmacological properties, including hepatoprotective and antipyretic effects. This review consolidates historical, traditional, and scientific perspectives on glycyrrhizin, exploring its phytochemistry, therapeutic applications, and formulation potential. The plant has been valued since ancient times for its expectorant, demulcent, and gastrointestinal protective properties, and modern research highlights its broad-spectrum medicinal activities, including anti-inflammatory, antiviral, and antioxidant effects. With a focus on its utility in treating liver disorders and fever, this study examines extraction techniques, formulations, and pharmacological mechanisms. This review underscores the potential of glycyrrhizin as a natural therapeutic agent, paving the way for novel, effective, and economically viable formulations [1,2].