Introduction: Pittashaya ashmari (Cholelithiasis) is the presence of one or more calculi (gallstones) in the gallbladder. In children the gall bladder stone found in approximately 5%, between 30-70yrs of age the prevalence is up to 10% in male and 19% in females and increase in 70-80years old people to 30-40%. Its comparatively low in South India. Materials and Methods: A Hindu male patient aged about 48yrs, Married, working as Supervisor in private company, during his annual company check-up accidentally detected with 12.6 mm gall stone, since patient was Asymptomatic not taken any treatment for next 7 months. After 7 months due to his family physician advise, patient visited, Shalya tantra OPD, Shri Dharmasthala Manjunateshwara institute of Ayurveda & Hospital, Bengaluru. Patient was treated with Kadali Paneeya kshara -1gm (capsule) for 45days, after morning food. Outcome and results: Usg Abdomen & pelvis impression: Cholelithiasis within the lumen of gall bladder; largest measures 6.8mm. Discussion: Kadali Paneeya kshara which reduces the size of the stone without causing the any adverse effect to a patient.