In this study, the effects of curcumin's intermolecular interactions with ionic (CTAB) and non-ionic (SDS) surfactants on important physicochemical characteristics, including density, viscosity, pH, and conductivity at 310.15 K, are examined. The purpose of the study is to comprehend the effects of surfactants on the stability, solubility, and molecular behavior of curcumin in aqueous solutions. Because CTAB is cationic, it establishes significant electrostatic contacts with curcumin, increasing its molecular stability and solubility, according to experimental data. However, SDS stabilizes curcumin through hydrophobic interactions, though not as well as CTAB. Micelle formation is indicated by changes in density and viscosity, which modify molecular packing and the strength of interactions. Variations in pH imply that curcumin's interaction with surfactants influences proton dynamics, especially in solutions containing CTAB. The total physicochemical environment is impacted by ion mobility, which is influenced by surfactant-mediated micelle production, as confirmed by conductivity trends. These results demonstrate how surfactants may increase the bioavailability of curcumin for use in food, medicine, and cosmetics. The study opens the door for improved formulations in drug delivery and related disciplines by highlighting the significance of surfactant selection in improving curcumin's physicochemical properties.