The aim of this study is to explore foreign and local innovative practices in greening regions of Uzbekistan that are considered climatically unfavorable for plant cultivation, and based on this, to develop proposals and recommendations for greening desert areas and populated places in the Aral Sea region and improving their environmental conditions. The article examines plant cultivation and landscaping practices in large desert and sandy areas, particularly in China and Egypt, including the ongoing creation of the Serapium forests in the Egyptian deserts. The study analyzes how these practices could be applied in Uzbekistan’s regions unsuitable for plant growth, including saline and desert areas of the Aral Sea region. It also offers suggestions and recommendations for plant cultivation, desert greening, preventing sand drift in the Aral Sea deserts, and the use of wastewater (sewage water) for landscaping and reclamation in saline and desertified zones.