India has numerous naturally occurring, pharmacologically active plant compounds. Datura stramonium is a popular traditional medicinal herb. The problematic weed is a plant with both toxic and medicinal properties. It has been shown to have significant pharmacological potential and is used in folklore medicine. The Solanaceae family of medicinal plants contains the genus Datura, which has both toxic and therapeutic properties. Due to the number of bioactive components, the various plant parts of Datura spp., especially Datura stramonium L., often known as Datura or Jimson Weed, display powerful analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities.