First sodium ion in Saindhava (rock salt) actively absorbs from colon. High concentration of sodium ion facilitates sugar influx. Increase sodium ion in mucosal membrane generate osmotic gradient. Water follows this osmotic gradient thus passive absorption of water take place. Free fatty acid is easily absorbed by passive diffusion in the colon. From above description, it can be understood that how Saindhava, Madhu (Honey), Sneha and Kwatha (decoction) is absorb from the colon along with the Sneha (lipids) and Kwatha. Lipid and water-soluble portion are absorbed from the colon. According to modern pharmacokinetics, it is also proved that rectal drug administration might exceed the oral value due to partial avoidance of hepatic pass metabolism. Purvakarmas like local Snehana-Swedana & slightly warm temperature of the Basti may cause increased colonic permeability; thus, increasing the absorption.