Introduction: Cancers are the leading causes of morbidity and mortality worldwide, responsible for several million new cases and deaths. Pain is experienced by 55% of patients undergoing anti-cancer treatment and 65% of patients who have advanced, metastatic, or terminal diseases. It is said that chronic pain has its effects on the quality of life among cancer survivors. Aims and Objectives 1 To assess the level of pain among patients with cancer. 2 To assess the quality of life among patients with cancer. 3 To determine the effectiveness of guided imagery on pain and quality of life among patients with cancer 4 To determine the relationship between level of pain and quality of life among patients with cancer 5 To determine the association between level of pain among patients with cancer and selected demographic variables. 6 To determine the association between quality of life among patients with cancer and selected demographic variables’ Methodology a Quantitative Research approach was adopted by the researcher to find the effectiveness of guided imagery on pain quality of life among patient with cancer in selected hospital at Mehsana city. Data collection tools included demographic data & standardized verbal descriptor pain assessment scale. The pain assessment scale use to the pre-test, and a post-test was conducted after seven days. Data were analyzed using descriptive and inferential statistics, including paired t-tests and chi-square tests. Results The study findings are supported by Vasantha G, Almeida Victoria D, Kanagaraj R, (2013) conducted a experimental study effectiveness of guided imagery on intensity of pain and quality of life among 30 patients with cancer. The study revealed that the mean post-intervention intensity pain and quality of life score was lower than mean pre-intervention intensity of pain and quality of life score. The study concluded that guided imagery is an effective strategy in reducing the intensity of pain and improving the quality of life of cancer patients. The fifth objective was to assess the relationship between the level of pain and the quality of life. Table 6 shows the relationship between level of pain and quality of life among patients with cancer in post-test. The mean post-test score of pain was 0.75 with standard deviation 0.58 and mean post-test score of quality of life was 32.1 with standard deviation 3.23 Conclusion: The guided imagery is effective and simple strategy to reduce level of pain and improve the quality of life among patient with cancer.