Gastroesophageal reflux disease (GERD) affects individuals across various age groups, causing distressing symptoms such as heartburn, regurgitation, and chest discomfort. While conventional antacids offer rapid relief, their benefits are often short-lived, and gastrointestinal side effects can occur. Consequently, controlled-release drug delivery systems have been developed, providing a sustained release of medication over time. Notably, alginate-based delivery systems facilitate gradual medicine release, enhancing stability and absorption. This study focuses on developing and accessing magnesium hydroxide alginate beads as a controlled-release antacid formulation, aiming to alleviate acidity, prolong stomach retention for improved therapeutic outcomes, and achieve efficacy at lower doses.