Sex trafficking remains a pervasive issue affecting vulnerable populations across the United States, with Native American female youth in rural communities facing heightened risks due to factors such as historical trauma, systemic discrimination, and limited access to resources. This paper assesses the effectiveness of existing prevention and intervention programs targeting this demographic. The paper employs a comprehensive literature review and policy framework analysis. The study examines culturally responsive initiatives like the "Respecting the Circle of Life" program and the Indian Health Service's trauma-informed care practices. The findings revealed that though the aforementioned programs offer valuable insights and strategies, challenges persist, including insufficient culturally appropriate services, data limitations, and jurisdictional complexities that hinder effective intervention. The study also underscored that to effectively address sex trafficking among Native American female youth in rural areas, there is a need for programs that are culturally sensitive and community-driven to incorporate Indigenous knowledge and practices. Furthermore, the paper revealed that enhancing interagency collaborations and empowering Native voices are significant steps toward developing comprehensive solutions. This research underscores the importance of tailored approaches that address the unique vulnerabilities of this population, advocating for policy reforms and sustained efforts to create safe and supportive environments for Native American female youth.