The development of polyherbal bandages represents a promising advancement in wound care, integrating the therapeutic properties of multiple medicinal plants into a single dressing. These bandages are typically infused with bioactive compounds extracted from various herbs known for their antimicrobial, anti-inflammatory, and wound-healing properties. The synergistic action of these phytochemicals not only accelerates the healing process but also minimizes the risk of infection and scarring. In this study, a polyherbal bandage was formulated using extracts from Azadirachta indica, Curcuma longa, and Aloe vera, incorporated into a biocompatible base. The bandage was evaluated for its antimicrobial efficacy, biocompatibility, and wound-healing potential through in vitro and in vivo assessments. Results demonstrated significant antibacterial activity against common wound pathogens and enhanced epithelialization in treated wounds. These findings support the potential of polyherbal bandages as a natural, effective alternative to conventional wound dressings, with added benefits of reduced side effects and improved patient compliance.