This study presents the development and evaluation of a Clitoria ternatea-based nasal spray formulation aimed at providing rapid, non-invasive stress relief. Clitoria ternatea, known for its adaptogenic and anxiolytic properties, contains bioactive compounds such as flavonoids and anthocyanins that modulate oxidative stress and the hypothalamic-pituitary-adrenal (HPA) axis. Utilizing the intranasal route enhances the bioavailability of these compounds by enabling direct nose-to-brain delivery, bypassing the blood-brain barrier and first-pass metabolism.. These findings support the potential of Clitoria ternatea nasal spray as a fast-acting, plant-based therapeutic option for stress management.