The people of India have long revered the neem tree; for centuries, millions have cleaned their teeth with neem twigs, smeared skin disorders with neem-leaf juice, taken neem tea as a tonic, and placed neem leaves in their beds, books, grain bins, cupboards, and closets to keep away troublesome bugs. The neem oil is used for hair for growth of hair Given the use of various neem-derived products as pesticides and the realistic chances of residues derived from the treatments still being present at the time of consumption, there may be a risk for consumers. Therefore, in this study we present a review of the toxicological data from human and animal studies with oral administration of different neem- based preparations.