This study explores the translation and multilingual challenges associated with idiomatic expressions conveying the concept of “life” in English and Uzbek. Idioms, deeply rooted in cultural and cognitive frameworks, often lack direct equivalents across languages, making their translation complex. Through qualitative analysis of a selected corpus of idioms from both languages, this research examines semantic shifts, cultural adaptations, and strategies used to preserve meaning and stylistic effects. The findings highlight significant challenges in achieving equivalence, especially where cultural metaphors diverge. The study contributes to improved understanding of idiomatic translation and offers insights for translators and linguists working in multilingual contexts.