Nanotechnology is a multidisciplinary field with applications spanning agriculture, electronics, healthcare, textiles, construction, and cosmetics. Several hundred years back, India was advanced in traditional practices which were based on scientific knowledge. The Ancient Indian literature, Vedas and other texts demonstrate the intellectual property of Indians’ thinking in a variety of fields of study such as philosophy, arts, science and technology. There was a significant development of chemistry in ancient India. There were number of evidences that prove the use of nanotechnology in various applications of chemistry. At that time people knowingly or unknowingly use this technology for better or surprising results. This understanding has paved the way for advancements in various scientific and industrial domains.