The article presents the results of a clinical, laboratory and neuropsychological study aimed at assessing the effectiveness of an individualized rehabilitation program in patients with chronic cerebral ischemia stage I-II. The developed program included a cognitive-motivational module, physical training with biofeedback and nutraceutical support. According to the results of the 12-week intervention, the main group showed statistically significant improvements in cognitive functions (MoCA), a decrease in the severity of pain syndrome (VAS), an increase in the quality of life (SF-36), as well as a decrease in the levels of the proinflammatory cytokine IL-6 and homocysteine against the background of an increase in the neurotrophic factor BDNF. The results demonstrate the high effectiveness of an integrated approach to medical rehabilitation of patients with initial manifestations of chronic cerebrovascular insufficiency, which can help reduce the rate of progression of cognitive impairment and improve overall functional status.