Background: Sandhigata Vata is a prevalent degenerative joint disorder described under Vatavyadhi in Ayurvedic literature. It closely resembles osteoarthritis (OA) in modern medicine, characterized by joint pain, stiffness, and restricted mobility, especially in weight-bearing joints such as the knees and hips. The disease primarily occurs due to Dhatukshaya (tissue depletion), aggravated Vata Dosha, and is influenced by age, trauma, and lifestyle factors. Objective: To systematically review Ayurvedic perspectives on the etiology, pathology, clinical features, and management of Sandhigata Vata in relation to osteoarthritis. Materials and Methods: A qualitative review was conducted using classical Ayurvedic texts (Charaka Samhita, Sushruta Samhita, etc.) along with contemporary research and online databases including PubMed, Google Scholar, and Medline. Relevant references related to the causes, symptoms, differential diagnosis, and treatment modalities of Sandhigata Vata were compiled and analyzed. Results: Sandhigata Vata develops due to the vitiation of Vata Dosha and depletion of Kapha and Dhatus, leading to pain, swelling, and limited joint function. The disease lacks a dedicated chapter in Samhitas but is described under Vatavyadhi. Management involves a multifaceted approach including Snehana (oleation), Swedana (fomentation), Basti (medicated enema), Agnikarma (cauterization), and Jalaukavacharana (leech therapy). Herbal medications like Yogaraj Guggulu, Rasnasaptak Kwath, and Dashmool preparations are effective. Dietary and lifestyle modifications, along with yoga, support long-term disease control. Conclusion: Ayurveda offers a comprehensive and individualized approach to managing Sandhigata Vata through both preventive and curative strategies. Integration of classical therapies with modern insights provides sustainable and holistic care for osteoarthritis patients. Early diagnosis and a tailored combination of internal, external, and behavioral therapies can significantly enhance patient outcomes and quality of life.