The rapid evolution of digital commerce has been paralleled by increasingly sophisticated cybersecurity threats, placing, e-commerce platforms under unprecedented pressure to safeguard customer data, financial transactions, and operational integrity. Artificial Intelligence has become both a tool and a weapon—empowering defenders with advanced threat detection while enabling cybercriminals to launch automated, highly targeted attacks. Key challenges include surging credential theft, large-scale account takeovers, ransomware with double extortion tactics, supply chain compromises, and the exploitation of APIs and payment gateways. The growing use of deepfakes, malicious bots, and Fraud-as-a-Service further complicates the security landscape. At the same time, compliance with evolving global data protection regulations and the persistent shortage od skilled cybersecurity professionals exacerbate risks. This paper examines the major cybersecurity challenges confronting e-commerce in 2025, analyses their underlying drivers, and outlines strategies for building resilient, adaptive, and secure online retail ecosystems.