Skin disorders are common and affect a large number of people. Current treatment protocols are of palliative means thereby leading to its recurrence. Many formulations are used for different skin diseases. Rasataleshwar Rasa is an important formulation because it can be used for various skin problems such as Vicharchika, Kandu and Kitibha. Therefore, more research is needed to understand its preparation and effectiveness. The present study aimed to prepare and analyse Rasataleshwar Rasa as per the reference from Rasendrachintamani (Kushtharogadhikar). The formulation was prepared as per classical methods, beginning with the Shodhana of Parada, Gandhaka, Shankha, Gunja, and Bhallataka, followed by the preparation of Kajjali and Shankha Bhasma. Churna of selected herbal drugs was incorporated and triturated with Kumari Swarasa and Arka Ksheer, then subjected to Pachana in Gomutra. The final product was sun-dried, powdered, and obtained in Churna form. The study revealed distinct organoleptic features and significant variations in physicochemical parameters. Advanced analyses (XRD, XRF, and EDX) confirmed the molecular structure and elemental composition, including mercury, sulfur, and calcium carbonate. These findings highlight the need for further research to standardize Rasataleshwar Rasa and to establish its therapeutic potential in dermatological disorders.